The thesis describes a zero-dimensional model of the turbocharged Waukesha H24GL gas engine. It also briefly describes the models used for engine simulation and the advantages and disadvantages of certain types of models. Mathematical models of each of the main parts of the engine that are interconnected into a single unit are described. The engine model is modelled after an industrial eight-cylinder in-line turbocharged gas engine. The formation of the fuel mixture in general as well as the ignition delay during combustion and the formation of the fuel mixture in Otto gas engines in particular are described. A description of the optimization of engine performance and the influence of variable valve opening and turbocharger performance optimization is given. A brief technical description of the main parts and systems of the analysed engine is given along with the main technical characteristics of the engine. The Engine Simulation computer program from the British company Lotus Engineering was used to perform simulations of engine operation. By comparing the results of the engine operation simulation with the power and torque values of the real engine, it was concluded that the created engine model is valid and satisfactorily describes the operation of the real engine with minor deviations of the values obtained by the simulation from the actual engine values. The results of the simulation of the engine operation with and without the intercooler were also compared.